Cold agglutinin disease
COLD AGGLUTININ DISEASE IS A TYPE OF AUTOIMMUNE HEMOLYTIC ANEMIA (SEE THIS TERM) DEFINED BY THE PRESENCE OF COLD AUTOANTIBODIES (AUTOANTIBODIES WHICH ARE ACTIVE AT TEMPERATURES BELOW 30B0C)
Cold hemagglutinin disease; Idiopathic cold haemagglutinin syndrome; Idiopathic cold hemagglutinin syndrome; Cold agglutinin hemolytic anemia; Cold agglutination syndrome; Cold-hemagglutinin-test; Cold haemagglutinin disease; Anti-I agglutinin; Cold agglutinin syndrome; Autoimmune anemia due to cold-reactive antibodies; Primary chronic cold agglutinin disease; Primary cold agglutinin disease; Secondary cold agglutinin syndrome
Cold agglutinin disease (CAD) is a rare autoimmune disease characterized by the presence of high concentrations of circulating cold sensitive antibodies, usually IgM and autoantibodies that are also active at temperatures below , directed against red blood cells, causing them to agglutinate and undergo lysis. It is a form of autoimmune hemolytic anemia, specifically one in which antibodies bind red blood cells only at low body temperatures, typically 28–31 °C.